Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
aa2br_human 104 3.51x51 TM3 Y => Ter stop gained 3.76e-05 2 53196 0 None None
aa2br_human 121 4.41x41 TM4 R => Ter stop gained 6.6e-05 8 121204 0 None None
aa2br_human 125 4.45x45 TM4 V => SerfsTer14 frameshift 8.243e-06 1 121318 0 None None
aa2br_human 137 4.57x57 TM4 G => Ter stop gained 8.237e-06 1 121408 0 None None
aa2br_human 214 5.70x70 TM5 Q => Ter stop gained 3.295e-05 4 121400 0 None None
aa2br_human 292 7.55x55 TM7 Y => Ter stop gained 4.979e-05 6 120496 0 None None GP (contact)
aa2br_human 312 8.65x65 H8 Q => Ter stop gained 8.326e-06 1 120100 0 None None
aa2br_human 319 C-term N => GlufsTer17 frameshift 8.336e-06 1 119964 0 None None
aa2br_human 8 1.33x33 TM1 A => E missense 0.000711 4 5626 0 0.11 0.322
aa2br_human 9 1.34x34 TM1 L => P missense 0.0003059 2 6538 0 0.04 0.006
aa2br_human 30 1.55x55 TM1 A => T missense 1.734e-05 1 57670 0 0.0 0.467
aa2br_human 30 1.55x55 TM1 A => D missense 1.69e-05 1 59168 0 0.0 0.845
aa2br_human 30 1.55x55 TM1 A => V missense 3.38e-05 2 59168 0 0.01 0.028
aa2br_human 33 1.58x58 TM1 G => D missense 2.671e-05 2 74888 0 0.2 0.98
aa2br_human 35 1.60x60 TM1 A => V missense 0.002522 218 86428 4 0.0 0.058
aa2br_human 35 1.60x60 TM1 A => G missense 1.157e-05 1 86428 0 0.0 0.062
aa2br_human 37 12.49x49 ICL1 T => S missense 0.0002127 20 94026 1 0.99 0.002
aa2br_human 38 12.50x50 ICL1 L => R missense 1.017e-05 1 98312 0 0.0 1.0
aa2br_human 39 12.51x51 ICL1 Q => R missense 9.798e-06 1 102064 0 0.47 0.086
aa2br_human 43 2.40x40 TM2 N => T missense 0.0001902 21 110382 0 0.08 0.997
aa2br_human 43 2.40x40 TM2 N => S missense 9.059e-06 1 110382 0 0.07 0.99
aa2br_human 44 2.41x41 TM2 Y => C missense 8.961e-06 1 111594 0 0.27 0.999
aa2br_human 47 2.44x44 TM2 V => G missense 2.626e-05 3 114222 0 0.01 0.746
aa2br_human 58 2.55x55 TM2 L => V missense 8.517e-06 1 117408 0 1.0 0.989
aa2br_human 61 2.58x57 TM2 I => M missense 8.494e-06 1 117726 0 0.22 0.962
aa2br_human 62 2.59x58 TM2 P => L missense 8.5e-06 1 117652 0 0.02 1.0
aa2br_human 66 2.63x62 TM2 T => I missense 8.539e-06 1 117116 0 0.4 0.014
aa2br_human 70 2.67x66 TM2 G => V missense 1.726e-05 2 115866 0 0.0 0.977
aa2br_human 71 23.50x50 ECL1 F => L missense 8.656e-06 1 115528 0 0.92 0.06
aa2br_human 72 23.51x51 ECL1 C => Y missense 0.0002441 28 114730 2 0.33 0.767
aa2br_human 72 23.51x51 ECL1 C => F missense 8.716e-06 1 114730 0 0.24 0.691
aa2br_human 74 3.21x21 TM3 D => V missense 8.864e-06 1 112814 0 0.2 0.575
aa2br_human 75 3.22x22 TM3 F => L missense 9.129e-06 1 109540 0 0.01 0.493
aa2br_human 77 3.24x24 TM3 G => S missense 9.089e-06 1 110022 0 1.0 0.001
aa2br_human 79 3.26x26 TM3 L => V missense 1.869e-05 2 107018 0 0.0 0.889
aa2br_human 82 3.29x29 TM3 A => T missense 9.825e-06 1 101778 0 0.1 0.999
aa2br_human 85 3.32x32 TM3 V => M missense 2.074e-05 2 96434 0 0.26 0.79 LB (Van der Waals)
aa2br_human 85 3.32x32 TM3 V => L missense 1.037e-05 1 96434 0 0.38 0.569 LB (Van der Waals)
aa2br_human 90 3.37x37 TM3 Q => H missense 6.967e-05 6 86126 0 0.29 0.145
aa2br_human 92 3.39x39 TM3 S => F missense 1.231e-05 1 81254 0 0.0 1.0
aa2br_human 94 3.41x41 TM3 F => L missense 1.299e-05 1 76986 0 1.0 0.074
aa2br_human 96 3.43x43 TM3 L => F missense 0.0006907 51 73834 0 0.0 0.87
aa2br_human 98 3.45x45 TM3 A => V missense 2.994e-05 2 66800 0 0.0 0.55
aa2br_human 99 3.46x46 TM3 V => A missense 1.531e-05 1 65306 0 0.0 0.63
aa2br_human 107 3.54x54 TM3 I => S missense 2.11e-05 1 47386 0 0.0 0.036 GP (contact)
aa2br_human 113 34.53x53 ICL2 Y => F missense 8.413e-06 1 118870 0 0.0 0.95 GP (contact)
aa2br_human 115 34.55x55 ICL2 S => I missense 8.356e-06 1 119676 0 0.36 0.893 GP (contact)
aa2br_human 120 4.40x40 TM4 T => A missense 8.256e-06 1 121122 0 0.24 0.001
aa2br_human 120 4.40x40 TM4 T => S missense 8.254e-06 1 121154 0 0.15 0.002
aa2br_human 121 4.41x41 TM4 R => Q missense 1.65e-05 2 121232 0 0.0 0.026
aa2br_human 122 4.42x42 TM4 A => P missense 8.246e-06 1 121266 0 0.01 1.0
aa2br_human 123 4.43x43 TM4 R => S missense 1.649e-05 2 121318 0 0.4 0.999
aa2br_human 125 4.45x45 TM4 V => F missense 8.241e-06 1 121338 0 0.05 0.834
aa2br_human 126 4.46x46 TM4 I => F missense 8.241e-06 1 121348 0 0.0 0.827
aa2br_human 126 4.46x46 TM4 I => T missense 2.472e-05 3 121350 0 0.0 0.184
aa2br_human 127 4.47x47 TM4 A => G missense 8.24e-06 1 121352 0 0.69 0.008
aa2br_human 135 4.55x55 TM4 G => R missense 4.942e-05 6 121406 0 0.03 0.724
aa2br_human 136 4.56x56 TM4 I => F missense 8.237e-06 1 121408 0 0.0 0.999
aa2br_human 138 4.58x58 TM4 L => W missense 8.237e-06 1 121410 0 0.0 1.0
aa2br_human 141 4.61x61 TM4 F => S missense 1.647e-05 2 121410 0 0.0 0.931
aa2br_human 143 4.63x63 TM4 G => R missense 8.237e-06 1 121404 0 0.0 0.996
aa2br_human 149 ECL2 S => R missense 8.257e-06 1 121110 0 0.31 0.003
aa2br_human 150 ECL2 A => G missense 8.257e-06 1 121110 0 0.43 0.492
aa2br_human 152 ECL2 N => T missense 8.425e-06 1 118692 0 0.35 0.027
aa2br_human 155 ECL2 T => R missense 8.237e-06 1 121402 0 0.24 0.435
aa2br_human 157 ECL2 P => R missense 8.237e-06 1 121402 0 0.13 0.373
aa2br_human 162 ECL2 T => P missense 8.237e-06 1 121402 0 0.28 0.195
aa2br_human 162 ECL2 T => M missense 1.647e-05 2 121402 0 0.23 0.005
aa2br_human 171 45.50x50 ECL2 C => Y missense 8.237e-06 1 121402 0 0.0 0.743
aa2br_human 171 45.50x50 ECL2 C => S missense 8.237e-06 1 121402 0 0.0 0.414
aa2br_human 174 ECL2 E => Q missense 5.766e-05 7 121400 0 0.08 0.998
aa2br_human 180 5.36x38 TM5 S => C missense 8.238e-06 1 121396 0 0.0 0.954
aa2br_human 182 5.38x40 TM5 M => V missense 2.471e-05 3 121398 0 0.1 0.779 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
aa2br_human 182 5.38x40 TM5 M => I missense 8.237e-06 1 121400 0 0.0 0.881 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
aa2br_human 186 5.42x43 TM5 N => S missense 3.295e-05 4 121398 0 0.3 0.087 LB (Van der Waals)
aa2br_human 188 5.44x45 TM5 F => S missense 1.647e-05 2 121398 0 0.0 0.889
aa2br_human 193 5.49x49 TM5 P => S missense 1.647e-05 2 121398 0 0.07 0.364
aa2br_human 193 5.49x49 TM5 P => H missense 8.237e-06 1 121400 0 0.06 0.985
aa2br_human 196 5.52x52 TM5 L => F missense 8.237e-06 1 121400 0 0.05 0.697
aa2br_human 197 5.53x53 TM5 I => T missense 8.237e-06 1 121402 0 0.01 0.962
aa2br_human 200 5.56x56 TM5 V => G missense 8.237e-06 1 121402 0 0.7 0.226
aa2br_human 203 5.59x59 TM5 I => M missense 8.237e-05 10 121402 0 0.1 0.024
aa2br_human 206 5.62x62 TM5 F => C missense 8.237e-06 1 121402 0 0.0 1.0
aa2br_human 207 5.63x63 TM5 L => M missense 8.237e-06 1 121402 0 0.57 0.011
aa2br_human 207 5.63x63 TM5 L => P missense 8.237e-06 1 121402 0 0.04 0.687
aa2br_human 208 5.64x64 TM5 V => M missense 8.237e-06 1 121402 0 0.16 0.974 GP (contact)
aa2br_human 212 5.68x68 TM5 Q => E missense 8.237e-06 1 121402 0 0.0 0.969 GP (contact)
aa2br_human 214 5.70x70 TM5 Q => R missense 8.237e-06 1 121400 0 0.78 0.014
aa2br_human 215 5.71x71 TM5 R => H missense 8.237e-06 1 121400 0 0.05 0.007 GP (contact)
aa2br_human 219 ICL3 M => V missense 2.471e-05 3 121396 0 0.32 0.006
aa2br_human 223 6.24x24 TM6 R => W missense 8.237e-06 1 121400 0 0.0 0.988
aa2br_human 228 6.29x29 TM6 R => W missense 8.237e-06 1 121400 0 0.0 0.027 GP (contact)
aa2br_human 228 6.29x29 TM6 R => Q missense 8.237e-06 1 121398 0 0.07 0.09 GP (contact)
aa2br_human 236 6.37x37 TM6 L => V missense 8.237e-06 1 121406 0 0.0 0.999 GP (contact)
aa2br_human 241 6.42x42 TM6 G => R missense 8.237e-06 1 121408 0 0.07 0.998
aa2br_human 247 6.48x48 TM6 W => S missense 8.237e-06 1 121400 0 0.0 0.675 SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals)
aa2br_human 251 6.52x52 TM6 H => R missense 8.238e-06 1 121394 0 0.01 0.997 LB (polar (hydrogen bond), Van der Waals)
aa2br_human 256 6.57x57 TM6 V => I missense 8.241e-06 1 121340 0 1.0 0.003
aa2br_human 260 6.61x61 TM6 Q => H missense 8.249e-06 1 121224 0 0.59 0.009
aa2br_human 265 ECL3 K => E missense 8.255e-06 1 121138 0 1.0 0.328
aa2br_human 267 ECL3 K => E missense 8.258e-06 1 121102 0 0.84 0.458
aa2br_human 269 7.32x31 TM7 K => M missense 8.26e-06 1 121066 0 0.14 1.0
aa2br_human 269 7.32x31 TM7 K => N missense 8.261e-06 1 121048 0 0.41 1.0
aa2br_human 275 7.38x37 TM7 A => G missense 8.272e-06 1 120894 0 0.46 0.934
aa2br_human 276 7.39x38 TM7 I => V missense 1.654e-05 2 120890 0 0.0 0.958 LB (hydrophobic, Van der Waals)
aa2br_human 277 7.40x39 TM7 L => R missense 1.655e-05 2 120842 0 0.0 0.988
aa2br_human 281 7.44x43 TM7 A => V missense 8.281e-06 1 120752 0 0.1 0.977 SodiumPocket MicroSwitch
aa2br_human 288 7.51x51 TM7 I => T missense 8.292e-06 1 120598 0 0.0 0.017
aa2br_human 290 7.53x53 TM7 Y => H missense 8.295e-06 1 120556 0 0.0 0.463 SodiumPocket MicroSwitch
aa2br_human 293 7.56x56 TM7 R => W missense 0.0001162 14 120484 0 0.0 0.022 GP (contact)
aa2br_human 295 8.48x48 H8 R => Q missense 9.965e-05 12 120422 0 0.44 0.001 GP (contact)
aa2br_human 296 8.49x49 H8 D => H missense 8.306e-06 1 120396 0 0.02 0.999 GP (contact)
aa2br_human 296 8.49x49 H8 D => G missense 0.0001578 19 120376 0 0.01 0.998 GP (contact)
aa2br_human 298 8.51x51 H8 R => C missense 8.309e-06 1 120352 0 0.0 0.001 GP (contact)
aa2br_human 298 8.51x51 H8 R => H missense 6.648e-05 8 120328 0 0.01 0.001 GP (contact)
aa2br_human 305 8.58x58 H8 I => N missense 8.318e-06 1 120224 0 0.01 0.845
aa2br_human 307 8.60x60 H8 R => G missense 8.318e-06 1 120216 0 0.1 0.11
aa2br_human 307 8.60x60 H8 R => K missense 3.328e-05 4 120204 0 0.41 0.075
aa2br_human 308 8.61x61 H8 Y => C missense 8.321e-06 1 120180 0 0.21 0.051
aa2br_human 310 8.63x63 H8 L => F missense 1.665e-05 2 120136 0 0.04 0.845
aa2br_human 313 8.66x66 H8 A => G missense 8.329e-06 1 120058 0 0.2 0.021
aa2br_human 320 C-term G => A missense 1.669e-05 2 119846 0 0.11 0.437
aa2br_human 321 C-term Q => R missense 8.346e-06 1 119818 0 0.26 0.045
aa2br_human 323 C-term G => R missense 8.351e-06 1 119740 0 0.36 0.016
aa2br_human 325 C-term Q => R missense 9.201e-05 11 119550 0 0.15 0.045
aa2br_human 327 C-term A => T missense 1.676e-05 2 119358 0 0.46 0.001
aa2br_human 327 C-term A => D missense 8.382e-06 1 119308 0 0.06 0.073
aa2br_human 329 C-term G => S missense 1.679e-05 2 119138 1 0.82 0.0


Residue

Diagrams

ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
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